Winston-Salem State University was founded as the Slater Industrial Academy on September 28, 1892. It began in a one-room frame structure with 25 pupils and one teacher. In 1895, the school was recognized by the state of North Carolina, and in 1897 it was chartered by the Slater Industrial and State Normal School.
From the beginning, the school has insisted upon the vital importance of elementary school teachers in any program of building an improved citizenship. Emphasis has, therefore, constantly been placed upon the quality and quantity of training for these teachers. In 1925, the General Assembly of North Carolina recognized the school's leadership in this field; granted the school a new charter, extending its curriculum above high school; changed its name to Winston-Salem Teachers College; and empowered it under authority of the State Board of Education to confer appropriate degrees. Winston-Salem Teachers College thus became the first Negro institution in the nation to grant degrees for teaching in the elementary grades.
The Nursing School was established in 1953, awarding graduates the degree of Bachelor of Science. The basic nursing program covers four years of study with equal emphasis on academic and professional education.
In 1957, the North Carolina General Assembly revised the charter of the college and authorized the expansion of the curriculum to include secondary education and any other specific types of training as directed and determined by the State Board of Higher Education. The North Carolina General Assembly of 1963 authorized the changing of Winston-Teachers College to Winston-Salem State College. A statute designing Winston-Salem Teachers College as Winston-Salem State University received legislative approval in 1969.
On October 30, 1971, the General Assembly reorganized higher education in North Carolina, and on July 1, 1972, Winston-Salem State University (WSSU) became one of 16 constituent institutions of The University of North Carolina, subject to the control of a Board of Governors.